In this innovative intervention study in Gambia, Jaiteh et al. developed standard operative procedures (SOPs) for the care of common neurologic emergencies based upon syndromic diagnoses for stroke, fever with headache and seizure and found that in both rural and urban settings the availability of SOPs led to more appropriate evaluations and care. Larger studies with longitudinal assessments are likely needed to evaluate the impact on outcomes, but these findings suggest that a key role for the neurologist working in resource limited settings should be developing SOPs of this nature and assisting with implementation nationally.
China now has the dubious honor of having a stroke incidence rate on par with high-income Western countries but a stroke mortality rate that remains typical of a lower middle income country. Risk factors are the usual suspects—hypertension, a family history of stroke, dyslipidemia, atrial fibrillation, diabetes, physical inactivity, tobacco use and an elevated body mass index. Read more about this in the Neurology® article Rapid transitions in the epidemiology of stroke and its risk factors in China from 2002 to 2013 .
In this case-control study in a southern Han Chinese population, HLA-A* 24:02 was identified as a risk factor for Stevens-Johnson Syndrome (SJS) from exposure to antiepileptic drugs including carbamazepine, lamotrigine, and phenytoin. HLA-B* 15:02 polymorphisms in this population were an already recognized risk factor for SJS after similar exposures. The prevalence of the HLA-A* 24:02 polymorphism in this population remains unknown making it difficult to determine if routine screening is indicated.
Disclaimer: Blogs constitute the opinion of the author and do not reflect the views of the AAN or of Neurology ®
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Neurology mini-sites: New content and re-use of previously published Neurology content
Patricia K. Baskin, MS, Executive Editor and Robert A. Gross, MD, PhD, FAAN, Editor-in-Chief
Near the time this editorial is published, online readers of Neurology® will be able to access 2 new subspecialty satellite or mini-sites, which will carry articles in a particular topic area. These sites, which can be reached by links from the Neurology home page, will focus on health services topics (Innovations in Clinical Neurology) or global neurology (Without Borders). Both topics ... Full Text